The human body produces the chemical SAMe. The body makes all it needs and is rarely deficient. Possibly effective for treatment of depression and osteoarthritis. Weak evidence suggests possible benefit for fibromyalgia and intrahepatic cholestasis.
Attention for Liver Disease: Claims that SAMe helps liver conditions have not been proven, although results are still pending from an NIH study looking at SAMe and alcoholic liver disease.
Safety Information: Headache, upset stomach, flatulence, nausea and diarrhea are common side effects. Anyone with Parkinson’s or bipolar disorder should avoid SAMe.
Interactions: Avoid using if taking antidepressant medications as there is a risk of serotonin syndrome. Do not take if using cough medicine with dextromethorphan. May interact with Demerol, tramadol, or levodopa.
Lab Notes: None reported.
Note: SAMe is very expensive and unstable. Be sure to use a well-tested formulation.