Research has not substantiated the efficacy of valerian for treating insomnia.
Attention for Liver Disease: May be liver toxic, however, there are some doubts surround other claims of its hepatotoxic qualities, since all the reports used valerian in combination with other herbs. Until safety reports can be verified or disputed, it is recommended that people with liver disease avoid valerian or use extra caution, particularly if taking other supplements. Because it appears to interact with cytochrome p-450 metabolized substances (see Cytochrome P-450), do not take during HCV treatment..
Safety Information: May cause daytime sleepiness. Use cautiously when driving or operating machinery. May cause headaches, dizziness, constipation, gastric complaints, nervousness, blurred vision, insomnia, light- headedness, tightness in the chest, restlessness and slowing or irregular heartbeat. Symptoms of withdrawal may occur if stopping after long-term use of valerian. Safety has not been established for children, pregnant or nursing mothers.
Interactions: May interact with muscle relaxants, sedatives, anti-anxiety, pain, anti-seizure, antidepressant, or other drugs or supplements that cause drowsiness. May interact with any cytochrome p-450 metabolized substances (see Cytochrome P-450).
Lab Notes: None reported.
Note: Valerian may need to be taken on a regular basis for at least 4 weeks before results are evident.