HCV Advocate Newsletter: 2017
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- Alan’s coverage includes: final results from a phase 3 study of glecaprevir plus pibrentasvir (one pill/once-a-day) to treat genotype 3; a phase 2 study of MK-3682/grazoprevir plus ruzasvir to treat people who previously failed direct-acting antiviral therapy; treatment with sofosbuvir/velpatasvir plus voxilaprevir (one-pill, once-a-day) in treatment experienced patients with resistance and finally a study comparing liver cancer outcomes in people achieving a cure with interferon-based therapies vs. direct-acting antiviral therapies.
- Lucinda’s coverage includes: high cure rates with legally imported generic HCV drugs; Harvoni in patients with HCV/HBV coinfection; Harvoni +/– ribavirin treatment in children with chronic hepatitis C and lastly physical activity and cardiorespiratory fitness levels in people living with hepatitis C.
- Matthew’s coverage includes: a study of a viral load point-of-care test that has the potential to improve the HCV treatment cascade and the long-term gender differences in outcomes among people with hepatitis B and hepatitis C.
- The Drug Pipeline is be updated on a monthly basis and is always included with the HCV Advocate Newsletter
- What’s Up! Have you listened to our new voiceovers? We have added voiceovers to some of our most popular Easy C fact sheets – check them out!
- Lucinda’s Highlights from ILC 2017: Marijuana and liver transplant waitlist; expanding age-based testing; health-related quality of life and children treated with sofosbuvir and ribavirin; the effect of cholesterol and low-density lipoprotein after DAA treatment, and cardiovascular and cerebrovascular effects after DAA therapy.
- Alan’s Highlight’s from ILC 2017: Prevalence of concomitant substance abuse and mental health disorders in a HCV treatment program; factors associated with spontaneous viral clearance; treatment of acute HCV in people with HIV; treatment of HCV in New Mexico prison using telemedicine.
- Matthew’s Highlight’s from ILC 2017: Group medical intervention to improve HCV uptake among PWIDs in a primary care setting; 4 weeks of DAA treatment + ribavirin +/- pegylated interferon to treat PWIDs; evaluation of homeless on HCV treatment among PWIDs.
- Monday June 5th – Vestavia, Alabama
- Wednesday June 7th –Montgomery, Alabama
We have added a voiceover feature to some of our Easy C Fact Sheets:
What are Ravs / Viral Load Test / Taking HCV Meds / Ribavirin Warning
Hepatitis B Warning / Hepatitis C Antibody Test / Drug Resistance\What is HCV Genotype?
What is ALT? / What is Subtype?
Instructions on how to listen to the voiceovers are included on an overview website page (here). I would be very interested in feedback from our readers on the current voiceovers and recommendations for voiceovers on other fact sheets. Thank You!
- HealthWise – Sleep: The Key to a Healthy Liver by Lucinda K. Porter, RN. In this month’s column Lucinda explores the connection between sleep, the liver, a person’s health and the dreaded daylight saving time.
- SnapShots—by Alan Franciscus. I discuss three studies: Zepatier to treat people with bleeding disorders, the transformation of HCV treatment from the interferon era to direct-acting antiviral era with the VA system and finally the incidence of fatty liver in people with HIV, HCV, HIV/HCV coinfection and those with neither—and the very surprising outcome from the study.
- Under the Umbrella—Five Ways Hepatitis C is Unique to Women by Matthew Zielske. Matthew lays out five important facts about women and hepatitis C that you may or may not know about women infected with hepatitis C.
- What’s Up!
- HealthWise – Why We Need to Treat Everyone Who Has Hepatitis C by Lucinda K. Porter, RN – Lucinda explores how to eliminate hepatitis C in this thought-provoking article.
- Under The Umbrella—The Pros and Cons of Learning about Hepatitis C on the Internet by Matthew Zielske—Matthew writes about the pros and cons of educating ourselves and others about hepatitis C on the internet.
- SnapShots by Alan Franciscus.In this month’s column I write about three studies—the new liver chemistry guidelines issued, potential liver injury from herbal and dietary supplements, and an analysis about the treatment using Zepatier in people with compensated cirrhosis.
- The Drug Pipeline has been pretty quiet this month with the exception of the news that AbbVie’s two drug combination of glecaprevir plus pibrentasvir to treat all genotypes (pan-genotypic) had been granted a FDA priority review-meaning that the drug approval process will be speeded up.
- What’s Up! – In this month notice we have updated the following fact sheets:
- HealthWise – Connecting the Heart and the Liver – Lucinda K. Porter, RN. Lucinda talks about the health of these important organs. The number of people who die from heart disease annually is staggering.
- Under The Umbrella—Harm Reduction and Hepatitis C – Matthew Zielske.Matthew discusses aspects of harm reduction geared towards hepatitis C transmission. He is also working on many new Harm Reduction fact sheets for the HCV Advocate Website. Three new fact sheets are listed below.
- SnapShots – Alan Franciscus. In this month’s column I cover three studies—deaths caused by hepatitis C among Mexican Americans, non-Hispanics Whites and non-Hispanic Blacks, the changes in the most common indications for liver transplants and transplant waitlists and finally, a study that looked at the best practice to screen people at risk (including Baby Boomers) for hepatitis C in an effort to increase screening. All three studies are very illuminating.
- Drug Pipeline — no changes in this month’s Drug Pipeline
- What’s Up! – New this month are three Harm Reduction Fact Sheets:
- Harm Reduction and Alcohol
- Harm Reduction and Indirect Sharing
- Harm Reduction Definitions
- Coming Mid-February: Hepatitis C Drug Pipeline and Conference Coverage – The new feature will be populated by our conference coverage from 2016, from EASL and AASLD, and future conferences as well as current and future articles about drugs in development.
- 2016 In Review: Check out what our staff picked as the top news of last year.
- Under the Umbrella – The Art of Seeing by Matthew Zielske—Matthew discusses the meaning of being an advocate – an inspiring article to bring in 2017
- HealthWise by Lucinda K. Porter RN – Lucinda writes and argues for the elimination of hepatitis C in the United States and globally.
- AASLD 2016 – Part 2 by Alan Franciscus-I write about drugs in development to treat hepatitis C, monitoring people who are at risk for liver cancer and treating hepatitis C in people who inject drugs.
- HCV Advocate Pipeline
- What’s Up!
- Paper PI – we have decided to close down the Paper PI newsletter since we cover all the news in our News and Pipeline Blog.
- HCV and Harm Reduction – we have launched a new series of fact sheets on Harm Reduction. The first piece is an Overview of Harm Reduction by Matthew Zielske.
- Easy C Fact Sheet – Hep C Prevention in a Household – A common concern for people living together. This simple fact sheet provides information on how to stay safe
- Easy C Fact Sheet – Beware of Hepatitis B – we have revised this fact sheet based on feedback. The actual cases of HBV reactivation are uncommon and occurred with pegylated interferon therapies and the new direct-acting antiviral therapies.